Invitrogen, a provider of essential life science technologies for research, production and diagnostics, announced the launch of the first high-density microarray for the profiling of non-coding RNAs.

 

The NCode Human and Mouse non-coding RNA microarrays consist of both non-coding RNA and messenger RNA (mRNA) content on the same array. The arrays are designed by Invitrogen and then manufactured by Agilent Technologies, a technology leader in communications, electronics, life sciences and chemical analysis, using its proprietary SurePrint technology.

Transcription, or the synthesis of RNA as directed by DNA, involves not only mRNA corresponding to the genes that are translated into proteins, but also tens of thousands of long non-protein-coding RNAs. These non-coding RNAs appear to comprise a vast hidden layer of genetic programming implicated in development and disease pathways in mammals.

"Non-coding RNA transcripts play a variety of roles in a cell, ranging from simple housekeeping to complex regulatory functions, and evidence is mounting that their expression is perturbed in many cancers. Because their function remains largely unknown, these transcripts represent a new frontier of molecular genetic, molecular biological, physiological and cell biological research," said Dr John Mattick, professor of Molecular Biology at the University of Queensland, Australia.

The NCode non-coding RNA microarrays contain sequences of RNA that do not code for proteins along with sequences of RNA corresponding to mRNAs, which are translated into proteins in a cell. The non-coding sequences were generated and subsequently validated by Prof Mattick's team at the Institute for Molecular Bioscience, and exclusively licensed by Invitrogen.