SymBio Pharmaceuticals and Eisai Co have concluded the license agreement for the co-development and commercialization of bendamustine hydrochloride in Japan, with exclusive rights retained by SymBio. 

Based on this agreement, SymBio shall grant co-development and exclusive commercialization rights to Eisai and, in return, receive upfront and development milestone payments of up to JPY4 billion in total. In addition, the companies plan to move forward with the development of several target indications through co-development.

In Germany, bendamustine hydrochloride has been used extensively for the treatment of non-Hodgkin's lymphoma, multiple myeloma and chronic lymphocytic leukemia. In Japan, bendamustine hydrochloride is currently being investigated in patients with low-grade non-Hodgkin's lymphoma, and is in the pivotal stage of clinical development prior to submission for approval.

By entering into this alliance with Eisai, which also focuses on oncology as one of its strategic therapeutic areas, SymBio aims to accelerate its business expansion efforts and maximize the market potential of bendamustine hydrochloride in Japan. Eisai, for its part, will further strengthen its full-scale business deployment in the oncology area in Japan with the addition of this drug to its extensive in-house anti-cancer pipeline products.

In a collaborative effort to address unmet medical needs, SymBio and Eisai will work in tandem to expedite the development of bendamustine hydrochloride so that it will be available for use by patients and healthcare professionals in Japan as early as possible.