Scientist have again achieved a great success by developing a new drug KG5, which kills off cancer and also could wipe out some of the most deadly forms of the disease. It also acts by cutting off the blood supply to tumours.This drug is expected to hit the market in 5years.
An international team of University of California says that the KG5 drug works by making cancer cells "commit suicide"; it stops tumorous cells from multiplying and they then shut themselves down, the 'Nature Medicine' journal reported. Scientists expect that the compound or its derivatives will be effective against a wide range of the fast growing and most dangerous cancers.
The team has since developed variants of KG5 that are 100-fold more powerful than the original drug. They hope one of these more powerful compounds will enter clinical trials on humans at Moores Cancer Center in San Diego within 18 months.
KG5 works in a totally different way to traditional therapies by altering the structure of a cancer growth protein, an enzyme known as RAF. According to Dr Julie Sharp of Cancer Research UK, "The next step will be to test these ideas with patients."
Scientist Prof David Cheresh said the drug "blocks the function of proliferation" and the malignant cells commit suicide when they can't multiply. Proved effective in tests against pancreatic, breast and kidney cancers, it could well have a positive effect on a broad range of other tumors.
The radical drug will bring fresh hope to patients with aggressive and deadly tumors and could be available in as little as five years, say the scientists, who hope to deliver it in pill form, which has very few side-effects.
It has been proved that new variants of KG5 are 100 times more powerful than the original.
Scientists hope that one of these more potent compounds will soon enter clinical trials. The research has been published online in the journal Nature Medicine.