Patients taking Selzentry, in combination with Combivir® (zidovudine/lamivudine) and selected by an enhanced sensitivity tropism test to screen patients, experienced a 68 percent rate of virologic suppression to undetectable levels, according to the MERIT ES.
MERIT ES is a reanalysis of 48-week efficacy and safety data from the MERIT (Maraviroc versus Efavirenz Regimens as Initial Therapy) study following retesting of screening samples using the newly launched enhanced sensitivity Trofile™ assay. This therefore represents a subset of the MERIT 48-week primary analysis population. The enhanced sensitivity test was not available at the time of the MERIT study and is the only version of Trofile currently available.
In the MERIT ES reanalysis 68 percent of patients in the Selzentry arm, and 68 percent of patients in the efavirenz arm – a current standard of care – achieved suppression of the virus to undetectable levels (less than 50 copies/ml). When the criterion of less than 400 copies/ml was used, the results were 73 percent with Selzentry, and 72 percent with efavirenz.
“The results of MERIT ES are exciting as they show that with an enhanced sensitivity tropism assay the efficacy rate of Selzentry shown in MERIT with the original Trofile assay is improved further,” said Michael Saag, Professor of Medicine and Director of the Center for AIDS Research at the University of Alabama at Birmingham, who presented the results. “These findings are important for patients and physicians and offer guidance for clinical practice with the only version of Trofile currently available.”